NUDT3 rs206936 is associated with body mass index in obese Japanese women

Endocrine Journal

Takato Ueno^3,20  Seika Kamohara^2,18  Yuji Matsuzawa¹³  Aya Kitamoto⁶  Shigeru Miyazaki⁷  Hajime Teranishi⁴  Kiyoji Tanaka¹⁴  Ikuo Mineo²  Atsushi Nakajima^2,17  Masato Yoneda^2,17  Kikuko Hotta⁶  Hidenori Ochi⁹  Takuya Kitamoto⁶  Takahiro Nakamura^2,10  Nobuyuki Miyatake^1,2  Hideyuki Hyogo⁹  Katsuto Tokunaga^2,8  Akihiro Sekine⁶  Shinichi Oikawa^3,19  Toshiie Sakata^2,22  Ryoya Komatsu^2,11  Yoshio Nakata¹⁴  Toshiaki Hanafusa^2,15  Tohru Funahashi^2,23  Kazuaki Chayama⁹  Kazuyuki Hamaguchi^2,5  Tomoaki Matsuo¹⁴  Hiroaki Masuzaki^3,21  Kazuaki Kotani¹³  Seiho Mizusawa⁴  Rina So¹⁴  Jun Wada¹²  Kazuwa Nakao⁶  Kentaro Yamada³  Naoto Itoh^3,16 

[1] Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan;Otemae Hospital, Osaka 540-0008, Japan;Division of Endocrinology and Metabolism, Department of Medicine, Kurume University, Kurume 830-0011, Japan;Center for Genomic Medicine, Unit of Genome Informatics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan;Department of Community Health and Gerontological Nursing, Faculty of Medicine, Oita University, Oita 879-5593, Japan;EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan;Tokyo Postal Services Agency Hospital, Tokyo 102-8798, Japan;Itami City Hospital, Itami 664-8540, Japan;Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8551, Japan;Laboratory for Mathematics, National Defense Medical College, Tokorozawa 359-8513, Japan;Rinku General Medical Center, Izumisano 598-0048, Japan;Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan;Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305-8574, Japan;Department of Internal Medicine (I), Osaka Medical College, Takatsuki 569-8686, Japan;Toyonaka Municipal Hospital, Toyonaka 560-8565, Japan;Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan;Health Science University, Yamanashi 401-0380, Japan;Division of Endocrinology and Metabolism, Department of Medicine, Nippon Medical School, Tokyo 113-8603, Japan;Research Center for Innovative Cancer Therapy, Kurume University, Kurume 830-0011, Japan;Division of Endocrinology and Metabolism, Second Department of Internal Medicine, University of the Ryukyus Faculty of Medicine, Okinawa 903-0215, Japan;Department of Internal Medicine 1, Faculty of Medicine, Oita University, Oita 879-5593, Japan;Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan

关键词: NUDT3;    Visceral adipose tissue;    Subcutaneous fat tissue;    Computed tomography;    Japanese;   

DOI  :  10.1507/endocrj.EJ13-0100

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(36)Cited-By(3)The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference, waist-hip ratio measurements and visceral fat area (VFA); the latter can be accurately measured by performing computed tomography (CT).In addition to environmental factors, genetic factors play an important role in obesity and fat distribution.New genetic loci associated with body mass index (BMI) and adiposity have been identified by genome-wide association studies (GWASs).This study utilized CT to investigate whether single nucleotide polymorphisms (SNPs) that confer susceptibility to higher BMI are associated with VFA, subcutaneous fat area (SFA), and the ratio of VFA to SFA (V/S ratio).We measured the VFA and SFA of 1424 obese Japanese subjects (BMI ≥ 25 kg/m2, 635 men and 789 women) who were genotyped for 13 single nucleotide polymorphisms (SNPs) reported by recent GWASs, namely, TNNI3K rs1514175, PTBP2 rs1555543, ADCY3 rs713586, IRS1 rs2943650, POC5 rs2112347, NUDT3 rs206936, LINGO2 rs10968576, STK33 rs4929949, MTIF3 rs4771122, SPRY2 rs534870, MAP2K5 rs2241423, QPCTL rs2287019, and ZC3H4 rs3810291.The G-allele of NUDT3 rs206936 was significantly associated with increased BMI (P = 5.3 × 10-5) and SFA (P = 0.00039) in the obese Japanese women.After adjustment with BMI, the association between rs206936 and SFA was not observed.This significant association was not observed in the men.The other SNPs analyzed were not significantly associated with BMI, VFA, SFA, or V/S ratio.Our results suggest that NUDT3 rs206936 is associated with BMI in Japanese women.

【 授权许可】

Unknown