Infectivity of Porcine Circovirus 1 and Circovirus 2 in Primary Porcine Hepatocyte and Kidney Cell Cultures

Journal of Veterinary Medical Science

Takuya HIRAI¹  Kazumoto SHIBUYA¹  Tetsuo NUNOYA¹  Takeshi IHARA¹  Toshiki SAITOH¹  Keigo NAKAMURA¹ 

[1] Nippon Institute for Biological Science

关键词: infectivity;    porcine circovirus;    primary porcine hepatocyte cultures;   

DOI  :  10.1292/jvms.68.179

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(3)Infectivity of porcine circovirus (PCV) 1 and PCV2 was examined in primary porcine hepatocyte culture by comparing that of PCV in primary kidney cell culture. The virus titer of PCV2-infected hepatocyte cultures was higher than that of the PCV1-infected hepatocyte cultures and the PCV-infected kidney cell cultures. The number of virus-positive cells was most abundant in PCV2-infected hepatocyte cultures as determined by immunohistochemistry and/or in situ hybridization. The results of our data suggest that PCV2 preferably infects cultured hepatocytes as observed in the liver of pigs with postweaning multisystemic wasting syndrome.

【 授权许可】

Unknown