Effects of Infestation by Rhipicephalus sanguineus on Lymphocyte Blastogenic Responses to Mitogens in Dogs

Journal of Veterinary Medical Science

Takafumi ONISHI¹  Kouichi OHNO¹  Hisashi INOKUMA¹  Takako AITA¹ 

[1] Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University

关键词: canine;    lymphocyte mitogenesis;    Rhipicephalus sanguineus;   

DOI  :  10.1292/jvms.60.1013

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(25)Cited-By(7)Mitogen blastogenic responses of lymphocytes from dogs infested with adult Rhipicephalus sanguineus and the effects of salivary gland extracts (SGE) of the tick on the blastogenic responses of lymphocytes from normal dogs were studied. Infestation by R. sanguineus significantly suppressed concanavalin A, phyto-hemagglutinin and pokeweed mitogen responses of lymphocytes from dogs. The inhibition of lymphocyte responses of dogs in the first infestation was greater than that in the second infestation. SGE from R. sanguineus also suppressed all mitogen blastogenic responses of lymphocytes from healthy dogs in vitro. These suppressive effects of SGE on the blastogenic responses of PBL to mitogens were significantly inhibited by trypsin digestion. It is suggested that some proteins in SGE contribute to the suppressive effects of SGE on the blastogenic responses of peripheral blood lymphocytes from dogs.

【 授权许可】

Unknown