A syntenin-like protein with postsynaptic density protein (PDZ) domains produced by black tiger shrimp Penaeus monodon in response to white spot syndrome virus infection

Diseases of Aquatic Organisms

Phuwadol Bangrak¹  Wilaiwan Chotigeat¹  Amornrat Phongdara¹  Kidchakan Supamattaya¹  Potchanapond Graidist¹ 

关键词: White spot syndrome virus;    Penaeus monodon;    Signal transduction;    Syntenin;    Postsynaptic density protein;    PDZ;   

DOI  :  10.3354/dao049019

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: We report the isolation and characterization of products from a subtractive cDNA library from the haemolymph of Penaeus monodon experimentally infected with white spot syndrome virus (WSSV). One cDNA derived from up-regulated mRNA wasidentified. A homology search indicated similarity to the putative protein syntenin (TE8). The nearly complete nucleotide sequence of TE8 was obtained by rapid amplification of cDNA (RACE). Its putative protein product contained a tandem repeat of PDZdomains (postsynaptic density protein or PSD-95, DlgA and ZO-1). We propose that TE8 may function as an adapter that couples PDZ-binding protein(s) in a signaling pathway involved in the shrimp response to WSSV.

【 授权许可】

Unknown