Therapeutic Effect of Modified Oligopeptides from the Beetle Allomyrina dichotoma on Methicillin-resistant Staphylococcus aureus (MRSA) Infection in Mice

Journal of Veterinary Medical Science

Ai ASAOKA¹  Kenji HIKOSAKA³  Hisako SAIDO-SAKANAKA¹  Manabu YAMADA³  Yukari KOYAMA³  Minoru YAMAKAWA¹  Yu YAMAMOTO³  Kikuyasu NAKAMURA³  Akira SHIMIZU²  Yoshikazu HIROTA³ 

[1] National Institute of Agrobiological Sciences;University of Kobe;National Institute of Animal Health

关键词: Allomyrina dichotoma;    defensin analogue;    histopathology;    methicillin-resistant Staphylococcus aureus (MRSA);    mouse;   

DOI  :  10.1292/jvms.67.1005

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(14)Cited-By(11)Anti-bacterial activity of two synthesized oligopeptides, RLYLRIGRR-NH2 (peptide A) and RLRLRIGRR-NH2 (peptide B), both which based on a putative active site of defensin, an anti-bacterial peptide from the beetle Allomyrina dichotoma, was examined by macroscopic and histopathologic assessment during the course of infection in mice inoculated with methicillin-resistant Staphylococcus aureus (MRSA) in vivo. Both peptides A and B decreased the mortality of mice inoculated with MRSA. Peptides A and B decreased the macroscopical and histopathological lesions by MRSA infection in mice even seven days after the challenge. The anti-bacterial activity of peptides A and B has a therapeutic effect on MRSA infection in mice even seven days after being challenged.

【 授权许可】

Unknown