Nandrolone decanoate (Deca-durabolin®) effect on hematologic parameters and total plasma protein of rats (Rattus rattus) with depressed bone marrow induced by vincristine (Oncovin®)

Ciência Rural

Oliveira, Sylvia Bonci de²  Hucke, Érica Engelberg Teixeira da Silva²  Varzim, Fernanda Leme Silva Bastos¹  Perez, Regina Raquel²  Silva, Maria Adriana Machado Lobo e² 

[1] Centro Universitário da Fundação de Ensino Octávio Bastos, Caconde, Brasil;Centro Universitário da Fundação de Ensino Octávio Bastos, São João da Boa Vista, Brasil

关键词: stimulant;    bone marrow;    rat;    nandrolone decanoate;    vincristine    INTRODUÇÃONo tratamento das neoplasias humanas e dos animais domésticos;    a quimioterapia tem sido a conduta de escolha;    mesmo estando amplamente documentado que esses medicamentos podem provocar efeitos colaterais indesejáveis;    como depressão medular (PARCHMENT et al;   

DOI  :  10.1590/S0103-84782005000300015

学科分类：农业科学（综合）

来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais

【 摘 要 】

In veterinary practice it is common to submit animals to chemotherapy for neoplasia control and to observe bone marrow depression, with presence of anemia, leukopenia and thrombocytopenia as collateral effects. In these cases, two therapeutical protocols can be adopted: chemotherapy by suppression and/or use of bone marrow stimulants. Nandrolone decanoate (Deca-durabolin®) is a bone marrow stimulant used in veterinary medicine despite few studies were conducted in domestic animals. The objective of this study was to analyse nandrolone decanoate (ND-1,5mg/kg, intramuscular), as a bone marrow stimulant in rats (Rattus rattus) with medular suppression induced by 4 and 8 mg/m2 (intraperitoneal) of vincristine (Oncovin®). Hemogram, platelets counting and total plasma protein determination were evaluated. These results showed that its effectiveness in bone marrow stimulation depends on the degree of depression and the dose of administration.

【 授权许可】

CC BY-NC