Overall survival analysis in oral squamous cell carcinoma patients diagnosed at the National Cancer Institute in 1999

Revista Brasileira de Epidemiologia

Camisasca, Danielle Resende¹  Silva, Licínio Esmeraldo da¹  Faria, Paulo Antônio Silvestre de²  Dias, Fernando Luiz²  Lourenço, Simone de Queiroz Chaves¹  Honorato, Julia¹ 

[1] Universidade Federal Fluminense;Instituto Nacional de Câncer

关键词: Squamous cell carcinoma;    Oral cancer;    Prognosis;    Survival analysis;   

DOI  :  10.1590/S1415-790X2009000100008

学科分类：过敏症与临床免疫学

来源: SciELO

【 摘 要 】

Oral squamous cellcarcinoma accounts for 90 to 95% of all malignant neoplasms of the mouth andit is one of most common cancers in Brazil. Five-year survival rates remainlow and have not improved over the past decades, despite advances in therapy.The purpose of this study was to analyze the features and overall survival ofpatients diagnosed with oral squamous cell carcinoma in 1999 at the NationalInstitute of Cancer. Male patients (79.4%) with a medium age of 56.7 years,with smoking or drinking habits (82.2%) comprised most of the sample. Tongueand floor of the mouth were the most prevalent sites of occurrence. Patientswere diagnosed mainly at advanced stages of the disease (68.9% stages III andIV) and were treated with radiation therapy alone (53.6 %). Mean survival was29.4 months, and patients diagnosed in early stages had better survival rates,as well as those who were surgically treated and those who did not show cervicalnode metastasis at diagnosis. Tumors located in the palate or in the buccalmucosa presented the worst prognosis. Cox regression analysis showed that T1or T2 lesions (p=0.001), with no neck metastasis (p=0.012) and anatomic siteother than buccal mucosa (p=0.021) were independent predictive factors of abetter survival rate. Oral cancer diagnosis still occurs in advanced stages,and it negatively influences overall survival, so there should be efforts toprepare and train professionals to recognize lesions at early stages and tomake the population at greatest risk aware of the disease.

【 授权许可】

CC BY