期刊论文详细信息
Endocrine Journal
Intramuscular 3-Hydroxybutyrate Levels after 60Tetani/Min Contraction in Diabetic and Non-Diabetic Rats
NAOYA NAKAI2  YOSHIHARU SHIMOMURA1  ISAO OHSAWA2  JUICHI SATO2  YOSHIHARU OSHIDA2  YUZO SATO2 
[1] Nagoya Institute of Technology;Research Center of Health, Physical Fitness and Sports, Nagoya University
关键词: 3-Hydroxybutyrate;    Microdialysis;    Muscle contraction;    Diabetes;   
DOI  :  10.1507/endocrj.45.363
学科分类:内分泌与代谢学
来源: Japan Endocrine Society
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【 摘 要 】

References(21)Cited-By(1)Post-exercise hyperketonemia in poorly-controlled diabetic patients is a well recognized phenomenon, but because studies concerning changes in ketone body metabolism in muscle during and/or after exercise are scarce, we measured the intramuscular 3-hydroxybutyrate (3-OHBA) and lactate concentrations in 12 diabetic (streptozotocin-induced; 60mg/kg, ip) and 13 non-diabetic control rats before and after a 1-h muscle contraction. One thigh tetanic contraction was elicited at a tetanic frequency of 60tetani/min and the other thigh was kept resting. We used a microdialysis technique in both quadriceps muscles, vastus lateralis, and the right jugular vein. Blood flow in both femoral muscles was also monitored before and after contraction. Dialysate 3-OHBA and lactate levels in contracting and non-contracting muscles and in blood showed a significant increase after contraction (P<0.05) in diabetic rats. In control rats there was no significant change in dialysate 3-OHBA or the lactate concentration in contracting and non-contracting muscles or in blood before and after contraction. A significant increase in contracting muscle blood flow was observed only for the first 5 min after contraction in diabetic and control rats. These results suggest that 3-OHBA uptake in contracting muscle is reduced, and that this phenomenon may play a role in post-exercise ketosis in diabetes.

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