Comparison of Toxicity between Saxitoxin and Decarbamoyl Saxitoxin in theMouse Bioassay for Paralytic Shellfish Poisoning Toxins

Journal of Veterinary Medical Science

Kenji MACHII¹  Hodaka SUZUKI¹ 

[1] Division of Biomedical Food Research, National Institute of Health Sciences, 1�?18�?1 Kamiyoga, Setagaya-ku, Tokyo 158�?8501, Japan

关键词: comparative toxicity;    decarbamoyl saxitoxin (dcSTX);    mouse bioassay (MBA);    saxitoxin (STX);   

DOI  :  10.1292/jvms.14-0211

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(7)Cited-By(2)The mouse bioassay (MBA) forparalytic shellfish poisoning (PSP) toxins has been used in the AOAC Official Method andthe official Japanese method. In the AOAC Official Method, the saxitoxin (STX) standardprovided by the U.S. Food and Drug Administration (FDA) is used, but no standard is usedin the official Japanese method. The objective of this study was to compare the toxicityof decarbamoyl STX (dcSTX), one of the derivatives of STX and a candidate standard for theMBA for PSP toxins in Japan, to that of FDA STX in the MBA platform. In this study, thetoxicity of dcSTX was 918.0 ± 44.9 mouse units/µmol, and the relativetoxicity ratio of dcSTX to FDA STX based on moles was 0.478.

【 授权许可】

Unknown