Site-Dependent Differences in Collagen Lamellae in the Corneal Substantia Propria of Beagle Dogs

Journal of Veterinary Medical Science

Prasarn TANGKAWATTANA³  Yuji TANAKA¹  Aya NAGAYASU²  Tomoe HIRAYANAGI²  Kazushige TAKEHANA²  Hiromi UEDA² 

[1] Department of Ophthalmology and Visual Science Tohoku University Graduate School of Medicine;Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University;Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Khon Kean University

关键词: canine;    collagen fibrils;    collagen lamellae;    cornea;    corneal substantia propria;   

DOI  :  10.1292/jvms.71.1229

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(1)The fine structure in the center and periphery of the cornea of 16 beagle dogs were characterized and compared. The central cornea (about 540 μm) was apparently thinner than the peripheral cornea (about 720 μm). Thickness ratios of the corneal substantia propria to the entire cornea were approximately 86% in both portions. In addition, number of collagen lamellae, collagen fibril diameter, and collagen fibril index of the central substantia propria are different from those of the periphery (253 vs 236 lamellae, 29.1 vs 32.0 nm, and 39.0 vs 41.6%, respectively). These differences are thought to be due to site-dependent accumulation of proteoglycans (decorin and lumican) which are responsible for production of thin fibrils. The central portion with higher proteoglycans would have abundant thin fibrils with less slippage but better elasticity to buffer against the direct impact of intraocular pressure on the cornea. In contrast, thick fibrils in the peripheral substantia propria would contribute to the maintenance of tensile strength acting on the transition zone between the cornea and sclera.

【 授权许可】

Unknown