Aggressive Spindle Cell Rhabdomyosarcoma in an 11-Month-Old Boxer Dog

Journal of Veterinary Medical Science

Marcello Rodrigues da ROZA¹  Márcia Cristina da Costa MIGUEL³  Nara BENATTO⁴  Fabiana Pirani CARNEIRO⁵  Rivadávio Fernandes Batista de AMORIM⁵  Mauricio BARRIVIERA² 

[1] School of Veterinary Medicine, Federal University of Goiás;Department of Radiology, School of Dentistry, Catholic University of Brasilia;Post-Graduate Program in Oral Pathology, School of Dentistry, Federal University of Rio Grande do Norte (UFRN);Sante Laboratory;Department of Pathology, School of Medicine, University of Brasília (UnB)

关键词: canine;    neoplasms;    rhabdomyosarcoma;    sarcoma;    spindle cell;   

DOI  :  10.1292/jvms.10-0082

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(2)Rhabdomyosarcoma (RMS) is a malignant neoplasm derived from mesenchymal tissue with a tendency toward myogenic differentiation associated with the embryogenesis of skeletal muscle. According to the histological features, it can be classified in embryonal, botryoid, alveolar, and pleomorphic, which usually correspond to clinical behavior and prognosis. The spindle cell (SCRMS) variant is a rare subtype of the embryonal RMS and is considered to be less aggressive lesion. The aim of the present paper is to report an unusual case of SCRMS in an 11-month-old male boxer dog diagnosed as extensive SCRMS that affected the frontal region of the skull. Due to the aggressive nature of the lesion and poor clinical prognosis the dog's owners preferred euthanasia as a treatment. A full postmortem examination was carried out. Microscopically, the lesion was composed of a highly cellular proliferation of spindle cells arranged in long and intersecting fascicles. After performing the immunohistochemical studies (HHF-35, smooth muscle actin, desmin and MyoD1), the present case was diagnosed as SCRMS.

【 授权许可】

Unknown