A Case of Adrenocorticotropin-independent Bilateral Adrenal Macronodular Hyperplasia (AIMAH) with Primary Hyperparathyroidism (PHPT)

Endocrine Journal

Mikano SATO²  Ryou SUZUKI²  Kazutoshi KOMATSU²  Kotoko KOSUGE²  Koichi MATSUMOTO²  Masahiko SUGITANI³  Tomohiro NAKAYAMA¹  Masayoshi SOMA²  Kazuyoshi OKADA² 

[1] Division of Receptor Biology, Advanced Medical Research Center, Nihon University School of Medicine;Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine;Department of Pathology, Nihon University School of Medicine

关键词: Bilateral adrenal tumor;    Cushing's syndrome;    Adrenalectomy;    Hypercalcemia;   

DOI  :  10.1507/endocrj.53.111

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(32)Cited-By(5)We report a rare case of ACTH-independent macronodular adrenal hyperplasia (AIMAH) with primary hyperparathyroidism (PHPT). A 57-year-old woman was admitted to our hospital for further examination of secondary hypertension and bilateral adrenal macrotumors. Midnight serum cortisol elevation with undetectable plasma ACTH, increased 24-hour urinary free cortisol excretion, and loss of the normal circadian rhythm in cortisol secretion established the diagnosis of Cushing's syndrome. Total resection of the enlarged left adrenal gland was performed with subsequent steroid replacement. Her general condition improved but serum calcium level increased 3 weeks after surgery. PHPT was diagnosed on the basis of endocrinological examination, although imaging studies failed to detect parathyroid lesion. In summary, we believe this to be the first report of a case of AIMAH with PHPT.

【 授权许可】

Unknown