Occurrence and susceptibilities to disinfectants of Cryptococcusneoformans in fecal droppings from pigeons in Bangkok, Thailand

Journal of Veterinary Medical Science

Nuvee PRAPASARAKUL¹  Prathomporn KRANGVICHAIN¹  Waree NIYOMTHAM¹ 

[1] Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand

关键词: Bangkok;    Cryptococcus neoformans;    disinfectant;    pigeon droppings;    susceptibility;   

DOI  :  10.1292/jvms.15-0594

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(31)Supplementary materials(1)Cryptococcus neoformans is an opportunistic pathogenic yeast that causesmeningoencephalitis and deep skin dermatitis in humans and animals. A hygienic strategyusing disinfectants on environmental samples can reduce the risk to the public. Theobjectives were to survey the distribution of C. neoformans in pigeonfecal droppings collected in 11 districts in Bangkok during 2011�?2012 and to evaluate theefficacy of three commercial disinfectant products (based on potassium monopersulfate,sodium hypochlorite and quaternary ammonium compounds, respectively). These were evaluatedagainst pure C. neoformans and yeasts resuspended in sterile pigeon fecesusing the dilution-neutralization method [Europäische NORM (EN) 1656]. In total, 18 of 164(11%) samples were positive for C. neoformans. These came from only threeof the 11 districts, with a prevalence of between 13�?56%. Using multiplex PCR, serotype Awas the sole group found. For all disinfectants, C. neoformans mixed infeces was tolerated at a higher dose and time exposure than pure isolates. The mosteffective disinfectant in this study was a 0.12% quaternary ammonium compound that couldrapidly eradicate the yeasts mixed in feces. This finding highlights the occurrence anddistribution of C. neoformans in the capital city of Thailand and theneed to prolong the duration of exposure to disinfectants with pigeon feces.

【 授权许可】

Unknown