Putative IgG4-related pituitary disease with hypopituitarism and/or diabetes insipidus accompanied with elevated serum levels of IgG4

Endocrine Journal

Ai Haraguchi¹  Kuniko Abe²  Takao Ando¹  Ikuko Ueki¹  Toshiro Usa¹  Katsumi Eguchi¹  Tomoki Origuchi¹  Ai Era¹  Junichi Yasui¹  Misa Imaizumi¹  Ichiro Horie¹ 

[1] First Department of Medicine, Nagasaki University School of Medicine, Nagasaki, Japan;Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan

关键词: IgG4;    Pituitary;    Hypopituitarism;    Diabetes insipidus;   

DOI  :  10.1507/endocrj.K10E-030

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(19)Cited-By(18)IgG4-positive plasma cell infiltration into multiple organs or tissues, such as the pancreas and salivary glands, associated with increased serum levels of IgG4 is a characteristic finding seen in IgG4-related disease. Affected organs may appear tumorous as a result of chronic inflammatory processes accompanied with progressive fibrosis. Recent cases of this disorder in which the pituitary gland was affected include cases of diffuse enlargement of the pituitary and/or its stalk associated with central diabetes insipidus and/or impaired anterior hormone production. Here we report two such cases, as well as two additional previously undiagnosed cases found in our database. In order to make a correct diagnosis of pituitary lesion involvement with IgG4-related disease, the clinical background and concomitant disorders should be carefully taken into consideration and the measurement of serum levels of IgG4 seems to be useful.

【 授权许可】

Unknown