A Case of a Pony with Cushing's Disease

Journal of Veterinary Medical Science

Yoshio MORIKAWA²  Fumihiko SASAKI²  Kiyohide YUGUCHI²  Yasuo KISO²  Toshiya OKADA²  Masaaki OIKAWA¹  Yasuo NAMBO¹ 

[1] Clinical Science and Pathobiology Division, Equine Research Institute, Japan Racing Association;Department of Veterinary Anatomy, College of Agriculture, Osaka Prefecture University

关键词: ACTH;    Cushing's disease;    pony;   

DOI  :  10.1292/jvms.59.707

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)Cited-By(3)The pars intermedia of the pituitary gland, and plasma ACTH and cortisol levels in the pony, which was first diagnosed in Japan as indicating equine Cushing's disease, were examined by immunohistochemistry and radioimmunoassay, respectively. The pars intermedia was greatly enlarged and most of its cells were immunoreactive for antisera to both adenocorticotropic hormone (ACTH) and β-endorphin (β-End). The plasma ACTH level was elevated when clinical symptoms appeared. The present results reveal that equine Cushing's disease in this pony was induced by the hypersecretion of ACTH and β-End from the enlarged pars intermedia of the pituitary gland.

【 授权许可】

Unknown