Canine Notochordal Cell-Secreted Factors Protect Murine and Human Nucleus Pulposus Cells from Apoptosis by Inhibition of Activated Caspase-9 and Caspase-3/7

Evidence-Based Spine-Care Journal

Arne Mehrkens²  M. Zia Karim¹  Michael G. Fehlings¹  Sarah Kim¹  William Mark Erwin¹  Raychel Hilario¹ 

[1] Toronto Western Research Institute, University of Toronto, Toronto, Canada;Department of Orthopaedic Surgery, Spine Unit, Basel University Hospital, Basel, Switzerland

关键词: disc degeneration;    notochordal cells;    rescue;   

DOI  :  10.1055/s-0033-1357363

学科分类：外科医学

来源: Thieme Medical Publishers, Inc.

【 摘 要 】

Introduction Effective therapies that may stop or even reverse disc degeneration remain elusive. A minimally invasive method through which nucleus pulposus (NP) cell viability could be achieved would revolutionize the treatment of degenerative disc disease (DDD). With the presented work, we have investigated if nonchondrodystrophic (NCD) canine intervertebral disc (IVD)-derived notochordal cell conditioned medium (NCCM) and chondrodystrophic (CD) canine IVD-derived conditioned medium (CDCM) are able to protect murine and human NP cells from apoptosis.

【 授权许可】

Unknown