Role of Lymphocytes in Spontaneous Regression of Experimentally Transplanted Canine Transmissible Venereal Sarcoma

Journal of Veterinary Medical Science

Toru FUJINAGA¹  Mitsuyoshi HAGIO¹  Shinya MIZUNO¹ 

关键词: canine interleukin-2;    lymphokine-activated killer cell;    major histocompatibility complex;    tumor infiltrating lymphocyte;   

DOI  :  10.1292/jvms.56.15

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(7)Sensitized peripheral blood lymphocytes (PBL) obtained from canine transmissible venereal sarcoma (CTVS)-regressed dogs were more cytotoxic against CTVS cells than non-sensitized PBL from untreated dogs. Cytotoxicity shown by sensitized PBL was inhibited significantly by the addition of anti-major histocompatibility complex (MHC) class II mouse monoclonal antibody as well as that of anti-dog thymocyte rabbit serum. The degree of cytotoxic activity shown by lymphokine activated killer (LAK) cells induced from non-sensitized or sensitized PBL was similar to that of the activity shown by sensitized PBL. These LAK activities were also prohibited by the addition of anti-dog thymocyte rabbit serum. Immunohistochemical examination demonstrated that MHC class II antigens were expressed on the surface membrane of CTVS cells and thymocyte antigens were detected on the surface of the tumor infiltrating lymphocytes. From the results mentioned above, lymphocytes which play a central role in tumor regression are considered to be T cells. These cells might recognize MHC class II antigens on the surface membrane of CTVS cells in tumor regression.

【 授权许可】

Unknown