Experimental Hyperlipemia Induces Insulin Resistance in Cats

Journal of Veterinary Medical Science

Naohito NISHII²  Aya MATSUU¹  Yoshiaki HIKASA¹  Haruka MAEDA¹  Yusuke MURAHATA¹ 

[1] Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University;Laboratory of Veterinary Pharmacotherapeutics, Faculty of Agriculture, Tottori University

关键词: feline;    hyperlipemia;    insulin;   

DOI  :  10.1292/jvms.11-0266

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(2)The effect of experimental hyperlipemia on insulin sensitivity was evaluated in seven healthy cats. Serum triglyceride and free fatty acid concentrations were significantly (P<0.05) higher when lipid-heparin was administered (2,894 ± 1,526 mg/dl and 4.54 ± 0.70 mEq/l, respectively) than when saline was administered (70 ± 42 mg/dl and 0.22 ± 0.08 mEq/l, respectively). A glucose clamp test revealed that the mean glucose infusion rate when lipid-heparin was administered (5.80 ± 0.67 mg/kg/min) was significantly (P<0.05) lower than when saline was administered (8.52 ± 1.83 mg/kg/min). These results suggest that experimental hyperlipemia induced insulin resistance in the healthy cats.

【 授权许可】

Unknown