Hypoxia inducible factor 1α expression and effects of its inhibitors incanine lymphoma

Journal of Veterinary Medical Science

Masaya IGASE²  Masaru OKUDA³  Takuya MIZUNO³  Kenji BABA³  Takako SHIMOKAWA MIYAMA³  Ayana KIMURA¹  Satoshi KAMBAYASHI³  Shunsuke NOGUCHI³  Kosuke KOBAYASHI¹ 

[1] Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine Yamaguchi University, 1677�?1 Yoshida, Yamaguchi 753�?8515, Japan;Laboratory of Molecular Diagnosis and Therapeutics, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677�?1 Yoshida, Yamaguchi 753�?8515, Japan;Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677�?1 Yoshida, Yamaguchi 753�?8515, Japan

关键词: canine lymphoma;    echinomycin;    HIF inhibitor;    hypoxia inducible factor;    xenograft model;   

DOI  :  10.1292/jvms.15-0258

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(37)Cited-By(1)Hypoxic conditions in various cancers are believed to relate with theirmalignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a majorregulator of the response to low oxygen. In this study, we examined HIF-1α expression incanine lymphoma using cell lines and clinical samples and found that these cells expressedHIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol,suppressed the proliferation of canine lymphoma cell lines. In a xenograft model usingNOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor.Our results suggest that HIF-1α contributes to the proliferation and/or survival of caninelymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat caninelymphoma.

【 授权许可】

Unknown