Possible Role of Insulin-Like Factor 3 in the Bovine Corpus Luteum

Journal of Veterinary Medical Science

Misato ABE¹  Keisuke KOZAI²  Kiyoshi OKUDA¹  Takuo HOJO¹ 

[1] Laboratory of Reproductive Endocrinology, Graduate School of Natural Science and Technology, Okayama University, Okayama 700–8530, Japan;Laboratory of Reproductive Physiology, Graduate School of Environmental and Life Science, Okayama University, Okayama 700–8530, Japan

关键词: bovine;    corpus luteum;    estrous cycle;    insulin-like factor 3;    insulin-like factor 3 receptor;   

DOI  :  10.1292/jvms.12-0423

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Insulin-like factor 3 (INSL3) is a local regulator in mammalian gonads, but little is known of its function in bovine corpus luteum (CL). Here, we show that RXFP2 protein, the receptor of INSL3, was expressed throughout the estrous cycle and significantly high at the early luteal stage compared to the regressed luteal stage. INSL3 stimulated progesterone secretion, but not prostaglandin F2α and viability in cultured luteal cells. Together, these results suggest that INSL3 plays a luteotropic role as a local regulator in the bovine CL.

【 授权许可】

Unknown