A Case of Renin-Producing Adrenocortical Cancer

Endocrine Journal

MUNEMICHI INABA²  MAKOTO IITAKA²  SHIGEHIRO KATAYAMA²  HIRONOBU SASANO¹  KAYO YAMANAKA²  TOSHISUKE MORITA² 

[1] The Department of Pathology, Tohoku University School of Medicine;The Fourth Department of Medicine, Saitama Medical School

关键词: Adrenal carcinoma;    Renin-producing tumor;    Hypertension;    Hypokalemia;    Trilostane;    Mitotane;   

DOI  :  10.1507/endocrj.47.119

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(14)Cited-By(3)Here we report a case of a renin-producing adrenocortical carcinoma. A 57-year-old woman was referred to our hospital complaining of thirst and generalized muscle weakness. She was diagnosed as being hypertensive and diabetic with associated hypokalemia and she had a hard elastic mass with a diameter of 10cm on the left side of her neck. An abdominal computed tomography scan revealed a suprarenal mass on the left side (8.5×8×6.5cm). Endocrinological examination demonstrated a marked elevation in the patient's serum glucocorticoid and sex steroid hormones as well as plasma renin activity. Histological examination of a sample taken from the neck mass revealed a metastasis from an adrenal carcinoma, which was stained positively with antibodies against cytochrome P450 and renin, establishing the diagnosis of a renin-producing adrenocortical carcinoma. Trilostane was effective in reducing serum cortisol levels, but mitotane was ineffective.

【 授权许可】

Unknown