Hepatoprotective action ofPterocarpus marsupiumagainst streptozotocin-induced oxidative stress

Egyptian Journal of Biology

RS Gupta¹  R Gupta¹ 

关键词: antidiabetic;    hepatotoxicity;    lipid peroxidation;    reduced glutathione;    serum glucose;    superoxide dismutase.;   

DOI  :  

学科分类：生物科学（综合）

来源: Egyptian-English Society for Biological Sciences

【 摘 要 】

Pterocarpus marsupium Roxb. (Leguminosae) is widely used in Ayurvedic medicine as „Rasayana. for management of various metabolic disorders including hepatotoxicity. Treatment of diabetic rats with methanol extracts of P. marsupium at 100 and 300 mg per kg-bwt per day for 21 days dose-dependently decreased serum glucose level. The higher dose exerted a protective effect on antagonized biochemical parameters such as reduced glutathione, superoxide dismutase and lipid peroxidation, and altered towards the normal levels hepatic mass, protein and glycogen content. In conclusion present results suggest antidiabetic, hepatoprotective as well as antioxidant effect of P. marsupium.

【 授权许可】

Unknown