Excess Urinary Iodine Is Associated with Autoimmune Subclinical Hypothyroidism among Egyptian Women

Endocrine Journal

Ahmed ALSAYED²  Adel AHMED³  Adel AZAB⁴  Adela M. GAD¹  Abeer ABDEL-FATTAH¹  Hoda ABDEL-BASET¹ 

[1] Internal Medicine Depart. Faculty of Medicine for Girls;Internal Medicine Department, National Research Center;Internal Medicine, Ain Shams University;Clinical Pathology Depart., Ain Shams University

关键词: Subclinical hypothyroidism;    Urinary iodine concentration;    Thyroid peroxidase antibody;   

DOI  :  10.1507/endocrj.K07E-165

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(26)Cited-By(15)Excessive iodine exposure was reported to be associated with thyroid dysfunctions.The aim of this study is to evaluate the link between excess urinary iodine as the prime indicator of excessive iodine intake and autoimmune subclinical hypothyroidism (SCH) among Egyptian women. Seventy three women with autoimmune SCH and 60 age- matched healthy women as controls were enrolled in this study. TSH, FT4, urinary iodine concentrations (UIC) and thyroid peroxidase antibody (TPOAb) were estimated. The levels of urinary iodine were significantly higher in patients with SCH as compared with control subjects, (326.97 112.98 vs. 274.45 98.75 ug/l, p<0.01). In patients with SCH, there was a significant correlation between UIC and TSH levels. Also, a significant correlation between UIC and TPOAb was found. We conclude that excessive iodine intake may trigger thyroid autoimmunity and eventually thyroid hypofunction among Egyptian women.

【 授权许可】

Unknown