The Presence of Disease-Associated Prion Protein in Skeletal Muscle of CattleInfected with Classical Bovine Spongiform Encephalopathy

Journal of Veterinary Medical Science

Yuichi MATSUURA²  Morikazu IMAMURA²  Kei FUJII¹  Kohtaro MIYAZAWA²  Soichi KAGEYAMA¹  Yoshifumi IWAMARU²  Takashi YOKOYAMA²  Takashi FUJII¹  Kentaro MASUJIN²  Shigeo FUKUDA¹  Hiroyuki OKADA²  Miyako YOSHIOKA²  Yuichi MURAYAMA² 

[1] Hokkaido Animal Research Center, Hokkaido Research Organization, Shintoku, Hokkaido 081�?0038, Japan;National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki 305�?0856, Japan

关键词: BSE;    muscle spindle;    prion;    skeletal muscle;   

DOI  :  10.1292/jvms.13-0363

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(2)The aim of this study was to investigate the presence of disease-associatedprion protein (PrPSc) in the skeletal muscle of cattle infected with classicalbovine spongiform encephalopathy (C-BSE). The study was carried out systematically in 12different muscle samples from 43 (3 field and 40 experimental) cases of C-BSE; however,muscle spindles were not available in many of these cases. Therefore, analysis becamerestricted to a total of 31 muscles in 23 cattle. Even after this restriction, low levelsof PrPSc were detected in the muscle spindles of the masseter, intercostal,triceps brachii, psoas major, quadriceps femoris and semitendinosus muscles from 3 fieldand 6 experimental clinical-stage cases. The present data indicate that small amounts ofPrPSc are detectable by immunohistochemistry in the skeletal muscles ofanimals terminally affected with C-BSE.

【 授权许可】

Unknown