Activation of Insulin Receptors by Lagerstroemin

Journal of Pharmacological Sciences

Shunsuke Takasuga¹  Tomo Sasaki¹  Ryoji Kasai²  Takeo Hayashi²  Naoe Sukenobu¹  Osamu Hazeki¹  Katsuji Hattori¹  Kazuo Yamasaki² 

[1] Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University;Division of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University

关键词: insulin;    lagerstroemin;    lipolysis;    glucose transport;    mitogen-activated protein kinase;   

DOI  :  10.1254/jphs.93.69

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(13)Lagerstroemin, an ellagitannin isolated from the leaves of Lagerstroemia speciosa (L.) Pers. (Lythraceae), was examined for its biological activities. In rat adipocytes, the compound increased the rate of glucose uptake and decreased the isoproterenol-induced glycerol release. In Chinese hamster ovary cells expressing human insulin receptors, it increased the Erk activity. These insulin-like actions were accompanied by the increased tyrosine-phosphorylation of the β-subunit of the insulin receptors. Tryptic digestion of the extracellular sites of the insulin receptors markedly increased the effective concentrations of insulin without changing those of lagerstroemin. Thus lagerstroemin was considered to cause its insulin-like actions by a mechanism different from that employed by insulin.

【 授权许可】

Unknown