Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

Journal of Veterinary Medical Science

Jiro ARIKAWA¹  Kumiko YOSHIMATSU¹  Shumpei P. YASUDA¹  Ima-Nurisa IBRAHIM²  Rika ENDO¹  Andre YUNIANTO²  Takaaki KOMA¹  Ervi SALWATI²  Kenta SHIMIZU¹ 

[1] Department of Microbiology, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060–8638, Japan;National Institute of Health Research and Development, Ministry of Health, Jl. Percetakan Negra 29, Jakarta 10560, Indonesia

关键词: epidemiology;    hantavirus;    Indonesia;    rodent;    Seoul virus;   

DOI  :  10.1292/jvms.12-0442

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonotic disease caused by hantavirus infection. Many HFRS cases have been reported in East Asia and North Europe, while the situation in Southeast Asia remains unclear. In this study, the prevalence of hantavirus infection in rodents and humans in Thousand Islands regency, which is close to the port of Jakarta, one of the largest historic ports in Indonesia, was investigated. A total of 170 rodents were captured in 2005, and 27 (15.9%) of the rodents were antibody-positive against Hantaan virus antigen in an immunofluorescence assay (IFA) and Western blotting. Despite the high prevalence in rodents, human sera collected from 31 patients with fever of unknown origin and 20 healthy volunteers in the islands in 2009 did not show positive reaction to the antigen in IFA. To identify the virus in rodents genetically, a total of 59 rodents were captured in 2009. Sera from the rodents were screened for antibody by ELISA, and lung tissues were subjected to RT-PCR. 20 (33.9%) of the 59 rodents were antibody-positive, and 3 of those 20 rodents were positive for S and M genome segments of hantaviruses. Genetic analysis showed that the viruses belonged to Seoul virus and formed a cluster with those in Vietnam and Singapore. These results suggest that a unique group of Seoul viruses has spread widely in Southeast Asia.

【 授权许可】

Unknown