Anticancer Photodynamic and Non-photodynamic Effects of Pterin Derivatives on a Pancreatic Cancer Cell Line

Journal of Pharmacological Sciences

Toshiyuki Arai²  Keisuke Makino⁴  Kouhei Yamashita⁵  Mitsuru Nonogawa⁴  Takashi Miyoshi⁵  Hiroko Mori³  Masataka Sasada¹ 

[1] School of Health Science, Faculty of Medicine, Kyoto University, Japan;Department of Anesthesia, Kyoto University Hospital, Japan;Department of Anesthesia, Higashiyama Takeda Hospital, Japan;Institute of Advanced Energy, Kyoto University, Japan;Department of Hematology and Oncology, Kyoto University Hospital, Japan

关键词: pterin derivative;    anticancer drug;    photodynamic effect;   

DOI  :  10.1254/jphs.08002SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)To evaluate the feasibility of two kinds of pterin derivatives, 2-(N,N-dimethylaminomethyleneamino)-6-formyl-3-pivaloylpteridin-4-one (DFP) and 2-(N,N-dimethylaminomethyleneamino)-3-pivaloylpteridin-4-one (DP), as anticancer drugs, their photodynamic and non-photodynamic effects on pancreatic cancer cell line Panc-1 cells were examined. For photodynamic effects, cell death 48 h after UV-A irradiation was more prominent in cells preloaded with DP than DFP. When cells were simply incubated for 96 h without irradiation, DFP induced cell death, while DP suppressed cell proliferation. Furthermore, DP was much more soluble in water than DFP. These findings collectively indicated that DP is more feasible as an anticancer drug than DFP.

【 授权许可】

Unknown