First outbreak of sleeping disease in Switzerland: disease signs and virus characterization

Diseases of Aquatic Organisms

Nicolas Diserens¹  Ralph Knüsel¹  Torunn Taksdal¹  Heike Schmidt-Posthaus¹  Monika Jankowska Hjortaas¹  Regula Hirschi¹ 

关键词: Sleeping disease;    Salmonid alphavirus;    SAV;    Subtype 2;    Pathology;    Trout;    Phylogenetic analysis;   

DOI  :  10.3354/dao02766

学科分类：生物科学（综合）

来源: Inter-Research

【 摘 要 】

ABSTRACT: Sleeping disease is a contagious disease mainly of freshwater farmed rainbow trout, caused by salmonid alphavirus (SAV) Subtype 2. Here we describe the first case in Switzerland. Pathological changes ranged from acute pancreas necrosis to more chronic lesions with complete loss of exocrine pancreas and simultaneous degenerative, inflammatory and regenerative heart and muscle lesions. The partial sequencing of SAV E2 and nsp3 genes placed the Swiss SAV variant within the Subtype 2 clustering together with freshwater isolates from UK and continental Europe. Although mortality stayed low, growth rates were significantly reduced, making the disease economically relevant.

【 授权许可】

Unknown