Lymphocytic Hypophysitis Presenting with Diabetes Insipidus

Endocrine Journal

NOBUO HASHIMOTO¹  JUN TAKAHASHI¹  HIDEKI SATO²  HIROYUKI KOSHIYAMA²  TAKAHIRO KANATSUNA³  TOSHIKIYO KOH²  SUMIO YORITA²  KATSUMI HAYAKAWA⁴  KAZUMASA NISHIMURA⁴ 

[1] Department of Neurosurgery, Kyoto University Faculty of Medicine;Divisions of Endocrinology, Kyoto City Hospital;Metabolism, Department of Medicine, Kyoto City Hospital;Department of Radiology, Kyoto City Hospital

关键词: Lymphocytic hypophysitis;    Diabetes insipidus;    Infundibulum;    Neurohypophysis;   

DOI  :  10.1507/endocrj.41.93

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(11)Cited-By(31)Lymphocytic adenohypophysitis is an autoimmune disorder of the anterior pituitary gland which usually occurs in a woman in the postpartum period. It has been considered that lymphocytic hypophysitis is confined to the adenohypophysis sparing the neurohypophysis, and that diabetes insipidus is not a clinical feature of the disorder. Here we report the case of a 50-year-old woman with lymphocytic hypophysitis which presented with diabetes insipidus. MRI indicated homogenous swelling of the whole pituitary gland, loss of the normal high intensity of the posterior pituitary, and thickening of the pituitary stalk. A biopsied specimen of the pituitary revealed diffuse lymphocytic infiltration. The diabetes insipidus was controlled by the administration of DDAVP. The anterior pituitary function was not greatly damaged, and no hormonal replacement therapy was necessary. We suggest that this case represents a variant of lymphocytic adenohypophysitis and/or lymphocytic infundibulo-neurohypophysitis, in which the chronic inflammatory process involves the infundibulum, adenohypophysis and neurohypophysis.

【 授权许可】

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