Antifungal Activities of the Combination of Tacrolimus and Itraconazole Against Trichophyton mentagrophytes

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA²  Ken OKABAYASHI²  Hiroko OZAWA²  Shinichi WATANABE¹  Rui KANO² 

[1] Department of Dermatology, Teikyo University School of Medicine;Department of Pathobiology, Nihon University School of Veterinary Medicine

关键词: antifungal activities;    tacrolimus;    Trichophyton mentagrophytes;   

DOI  :  10.1292/jvms.67.629

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(8)Cited-By(1)Tacrolimus was reported to have no antifungal activity against dermatophytes, but it might show a synergistic fungicidal activity with azoles against dermatophytes as in the case of pathogenic yeasts. Therefore, we examined the antifungal activity of tacrolimus combined with itraconazole (ITZ) against five strains of Trichophyton mentagrophytes by measuring cell growth and performing MIC (minimum inhibitory concentration) testing. The mean colony diameter of T. mentagrophytes on 1/10 diluted Sabouraud dextrose agar (dSDA) with tacrolimus combined with ITZ was significantly shorter than that on dSDA with tacrolimus or ITZ. MICs of tacrolimus, ITZ, and tacrolimus combined with ITZ against T. mentagrophytes were determined, respectively. The results revealed a synergistic activity of tacrolimus in combination with ITZ against T. mentagrophytes.

【 授权许可】

Unknown