A Case of Autoimmune Hypophysitis Associated with Asymptomatic Primary Biliary Cirrhosis

Endocrine Journal

SHIGEKI YABE¹  YOSHIO MURAKAMI²  JUNKO TANAKA²  KUNIO KOSHIMURA²  ISAO KOBAYASHI¹  MOTOI SOHMIYA²  MASATERU NISHIKI²  YUZURU KATO² 

[1] Department of Laboratory Medicine and Clinical Laboratory Center, Gunma University School of Medicine;First Division, Department of Medicine, Shimane Medical University

关键词: Anti-pituitary antibody;    Anti-mitochondrial antibody;    Asymptomatic primary biliarycirrhosis;    Hypopituitarism;   

DOI  :  10.1507/endocrj.45.697

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(12)Cited-By(4)We report a 61-year old male patient with panhypopituitarism complicated with asymptomatic primary biliary cirrhosis (PBC). Tl-weighted magnetic resonance imaging demonstrated high intensity of the anterior pituitary gland. There was no mass lesion or enlargement of the pituitary gland or the stalk. Immunoblot analysis of the patient's sera with rat pituitary antigens revealed a band with a molecular size of 22 kD. Anti-M2 mitochondrial antibody has been consistently positive for five years. Liver biopsy revealed portal hepatitis with periportal infiltration of the inflammatory cells. This is the first case report of autoimmune hypophysitis complicated with asymptomatic PBC.

【 授权许可】

Unknown