Outbreak of Multiresistant OXA-24- and OXA-51-Producing Acinetobacter baumannii in an Internal Medicine Ward

Japanese Journal of Infectious Diseases

María Luisa Azañedo³  Lorenzo Sánchez⁴  Juan Cobos²  Daniel Tena⁵  Rosario Sánchez²  Alfredo Espinosa⁴  Julia Bisquert⁵  Ignacio Otero⁶  Nora Mariela Martínez⁵  Ana Vindel³  David Sáez¹  Jesús Oteo¹ 

[1] Laboratorio de Antibióticos, Servicio de Bacteriología, CNM;Servicio de Medicina Preventiva, Hospital Universitario de Guadalajara;Laboratorio de Infecciones Intrahospitalarias, Servicio de Bacteriología, CNM;Servicio de Medicina Interna, Hospital Universitario de Guadalajara;Sección de Microbiología, Hospital Universitario de Guadalajara;Servicio de Urología, Hospital Universitario de Guadalajara

关键词: outbreak;    Acinetobacter baumannii;    nosocomial infection;    meningitis;    ST79;    OXA-24;    OXA-51;   

DOI  :  10.7883/yoken.66.323

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(23)Here we describe the clinical, microbiological, epidemiological, and molecular characterization of an outbreak of multidrug-resistant Acinetobacter baumannii (MRAB) involving 5 patients admitted to the internal medicine ward of our hospital. Over a 6-week period, 5 MRAB isolates were recovered from 5 patients, including 1 with fatal meningitis, 3 with skin and soft tissue infections, and 1 with respiratory colonization. One sample obtained during environmental monitoring in the ward was A. baumannii-positive. According to the pulsed-field gel electrophoresis typing results, the strains isolated from all patients and the environmental sample belonged to a single clone, identified as ST79 by multilocus sequence typing. The blaOXA-24 and blaOXA-51 carbapenemases were detected in all isolates. Four patients died, but only the death of the meningitis patient was probably related to the A. baumannii infection. The infection source was probably the hands of the healthcare workers because the outbreak strain was isolated from the surface of a serum container. The results of the present study revealed the importance of strict adherence to control measures by all healthcare workers because the consequences of noncompliance can be very serious.

【 授权许可】

Unknown