Molecular and Phenotypic Characteristics of CMY-2 β-Lactamase-Producing Salmonella enterica Serovar Typhimurium Isolated from Cattle in Japan

Journal of Veterinary Medical Science

Masaru SUGAWARA³  Haruo WATANABE⁵  Marimo KAWAKAMI¹  Masato AKIBA²  Junko KOMORI⁴  Hidemasa IZUMIYA⁵ 

[1] Kenchu Livestock Hygiene Service Center;Safety Research Team, National Institute of Animal Health;Aizu Livestock Hygiene Service Center;Iwaki Livestock Hygiene Service Center;Department of Bacteriology, National Institute of Infectious Diseases

关键词: AmpC β-lactamase;    blaCMY-2;    ESC-resistant Salmonella;    Salmonella Typhimurium;   

DOI  :  10.1292/jvms.10-0156

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(6)Isolates of extended-spectrum cephalosporin (ESC)-resistant Salmonella enterica serovar Typhimurium obtained from two different farms in Fukushima Prefecture, Japan, in 2007 were characterized in order to determine the genetic basis of resistance. ESC resistance in the two isolates was mediated by an AmpC β-lactamase encoded by the blaCMY-2 gene, which is located in a large self-transmissible plasmid in each isolate. The sizes of the blaCMY-2-carrying plasmids were different. The replicon types of the plasmids were I1-Iγ and A/C. The results of macrorestriction analysis and phage typing suggest a close relationship between both isolates. This is the first report of ESC-resistant S. Typhimurium isolated from cattle in Japan.

【 授权许可】

Unknown