Topographic Relationship between Senile Plaques and Cerebrovascular Amyloidosis in the Brain of Aged Dogs

Journal of Veterinary Medical Science

Mitsuru KUWAMURA¹  Tsuyoshi AWAKURA¹  Akinori SHIMADA¹  Chitoshi ITAKURA¹  Kuniyasu TAKADA¹  Takashi UMEMURA¹  Eisaku OHAMA¹ 

关键词: cerebrovascular amyloidosis;    dog;    immunohistochemistry;    senile plaque;    β-protein;   

DOI  :  10.1292/jvms.54.137

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(46)Cited-By(19)The distributions of senile plaques (SP) and cerebrovascular amyloidosis (CA) were studied by employing thioflavin S and modified Bielschowsky stains, and β-protein immunohistochemistry on serial sections of the brains of aged dogs older than 10 years. Mature and perivascular plaques, both of which contained compact amyloid deposits, always showed a close topographic relationship to CA. In contrast, the majority of diffuse plaques showed no topographic relationship to CA. Cell bodies of neurons and/or glia were almost always involved in the diffuse plaques. In addition, β-protein immunohistochemistry demonstrated amyloid deposits on the periphery of occasional neurons. These findings suggest that different mechanisms may be involved in the development of the different subtypes of SP in the brains of aged dogs.

【 授权许可】

Unknown