Determination of pediatric reference levels of FT3, FT4 and TSH measured with ECLusys kits

Endocrine Journal

Koichi Ito¹  Kenichi Sekiya¹  Hidemi Ohye¹  Ai Yoshihara¹  Koji Mukasa¹  Jaeduk Yoshimura Noh¹  Kunihiko Ito¹  Kenji Iwaku¹  Miho Suzuki¹  Yo Kunii¹  Masako Matsumoto¹  Akinobu Minagawa²  Natsuko Watanabe¹  Yuka Kosuga¹ 

[1] Ito Hospital, Tokyo 150-8308, Japan;Internal Medicine, Saitama Medical University, Iruma-gun, Saitama 350-0495, Japan

关键词: Pediatric reference range;    FT3;    FT4;    TSH;   

DOI  :  10.1507/endocrj.EJ12-0390

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(22)Cited-By(5)Reference ranges for serum thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) in children were set using the assay kits currently used in clinical settings.A total of 342 children (111 males and 231 females) who were negative for antithyroid antibodies (TgAb, TPOAb) and were found to have no abnormalities on ultrasonographic examination of the thyroid gland were divided into 6 age groups: 4-6 years (45 children), 7-8 years (40), 9-10 years (53), 11-12 years (65), 13-14 years (83), and 15 years (56) for the study.FT3, FT4 and TSH levels were determined by electrochemiluminescence immunoassay (ECLIA) (ECLusys FT3, FT4 and TSH).The reference range for FT3 (pg/mL) was 2.91-4.70 for the age group of 4-6 years, 3.10-5.10 for the age group of 7-8 years, 3.10-4.87 for the age group of 9-10 years, 2.78-4.90 for the age group of 11-12 years, 2.77-4.59 for the age group of 13-14 years, and 2.50-4.64 for the age group of 15 years .The reference range for FT4 (ng/dL) was 1.12-1.67, 1.07-1.61, 0.96-1.60, 1.02-1.52, 0.96-1.52, 0.95-1.53.The reference range for TSH (μU/mL) was 0.62-4.90, 0.53-5.16, 0.67-4.52, 0.62-3.36, 0.54-2.78, 0.32-3.00.Serum FT3, FT4 and TSH levels in children differ from those in adults.It is, therefore, of importance to perform evaluation of thyroid function in children using reference values appropriate for the chronological ages, because misdiagnosis of hypothyroidism or inappropriate secretion of TSH (SITSH) and oversight of mild subclinical hypothyroidism could occur if the diagnosis is made using reference values for adults.

【 授权许可】

Unknown