Failure of Killed Corynebacterium parvum in Induction of Protection in C57BL/6 Mice against Babesia rodhaini Challenge Infection

Journal of Veterinary Medical Science

Susumu MAKIMURA¹  Kozo ADACHI¹  Takako MATSUDA¹ 

关键词: Babesia rodhaini infection;    C57BL/6 mouse;    killed Corynebacterium parvum;   

DOI  :  10.1292/jvms.55.1025

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Cited-By(1)We examined the survival rate of C57BL/6 mice challenged with Babesia rodhaini 21 days post-killed Corynebacterium parvum (KCP) inoculation in comparison with ICR mice. All KCP-inoculated ICR mice survived the challenge infection, while all KCP-inoculated C57BL/6 mice died. To account in part for the difference in protective effects of KCP, stimulatory effects of KCP on splenic phagocyte chemiluminescence (CL) response were investigated in C57BL/6 and ICR mice. The KCP-inoculated ICR mice exhibited significantly higher CL values than ICR mice without KCP inoculation. No significant difference in CL value was observed between C57BL/6 mice with and without KCP inoculation. These results taken together, the lack of resistance of the KCP-inoculated C57BL/6 mice to B. rodhaini infection may be attributed in part to small stimulatory effect of KCP on splenic phagocytes.

【 授权许可】

Unknown