Detection of Inducible Nitric Oxide Synthase- and Nitrotyrosine-Positive Cells in the Lesions of Pericarditis Induced by Porcine Enterovirus Serotype 3 Infection

Journal of Veterinary Medical Science

Taekyun SHIN¹  Chasoo LEE³  Sungsoo CHO² 

[1] Department of Veterinary Medicine, Institute for Life Science, Cheju National University;ChoongAng Animal Disease Laboratory;College of Veterinary Medicine, Kyungpook National University

关键词: nitric oxide synthase (NOS);    pericarditis;    porcine enterovirus 3;   

DOI  :  10.1292/jvms.63.1017

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)The expression of inducible nitric oxide synthase (iNOS), an enzyme that produces nitric oxide, was examined in the hearts of pigs infected with porcine enterovirus serotype 3 (PEV3). Piglets orally infected with PEV3 developed tremors and paralysis 3-7 days post-infection. Affected animals had pericarditis and myocarditis. There were fibrin and inflammatory cell infiltrates (macrophages and neutrophils) in the pericardial sac and myocardium. Immunohistochemically, the majority of inflammatory cells in the pericardial sac were positive for iNOS and nitrotyrosine, an end product of nitric oxide. These results suggest that iNOS is upregulated in the pericardial lesion, and that increased nitric oxide production plays an important role in the development of PEV3-induced pericarditis and myocarditis.

【 授权许可】

Unknown