Journal of Pharmacological Sciences | |
High-Temperature, but Not High-Pressure, Conditions Alter Neuronal Activity | |
Naoya Takahashi1  Yuji Ikegaya1  Mika Mizunuma1  Atsushi Usami1  Norio Matsuki1  | |
[1] Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan | |
关键词: pressure; calcium imaging; neuronal network; | |
DOI : 10.1254/jphs.09031SC | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(14)Cited-By(5)We describe the effect of high pressure and high temperature on neuronal activity. Increased intracranial pressure is generally a pathological sign observed in intracerebral hemorrhage, brain edema, and brain tumor, yet little is known about how the hyperbaric pressure per se affects neuronal activity. Using a pressure/temperature-changeable perfusion chamber, we carried out functional multineuron calcium imaging to record spontaneous spiking activity simultaneously from about 100 neurons in hippocampal slice cultures. High-pressure conditions (up to 100 mmHg) did not alter the network excitability, whereas high-temperature conditions (up to 40°C) increased synchronized network activity. Thus, neurons are sensitive to feverish conditions, but the acute hyperbaric circumstance itself is unlikely to exert a detrimental effect on neuronal function.
【 授权许可】
Unknown
【 预 览 】
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RO201911300484897ZK.pdf | 283KB | download |