Effects of Enteric-coated Lactoferrin Tablets Containing Lactobacillus brevis subsp. coagulans on Fecal Properties, Defecation Frequency and Intestinal Microbiota of Japanese Women with a Tendency for Constipation: a Randomized Placebo-controlled Crossover Study

Bioscience of Microbiota, Food and Health

Min Jung BAE¹  Noriyuki SUZUKI²  Mamoru TOTSUKA¹  Makoto SHIMIZU¹  Misao KOIDE²  Norio IIDA²  Satoru MORISHITA²  Hoyoku NISHINO³  Keikichi SUGIYAMA²  Michiaki MURAKOSHI²  Tomoji ONO² 

[1] Department of Applied Biological Chemistry, University of Tokyo;Research and Development Headquarters, Lion Corporation;Kyoto Prefectural University of Medicine

关键词: double-blind placebo-controlled trial;    lactoferrin;    Lactobacillus brevis subsp. coagulans;    probiotics;    intestinal microbiota;    enteric-coated tablets;   

DOI  :  10.12938/bmfh.32.13

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

References(25)Cited-By(1)The effects of oral administration of enteric-coated tablets containing lactoferrin (LF; 100 mg/tablet) and heat-killed Lactobacillus brevis subsp. coagulans FREM BP-4693 (LB; 6×109 bacteria/tablet) on fecal properties were examined in 32 Japanese women (20�?60 years of age) with a tendency for constipation (defecation frequency at equal to or less than 10 times/2 weeks) by a double-blind placebo-controlled crossover design. A significant increase in defecation days per week was obserbed in the subjects who ingested the tablets containing LF and LB compared with the placebo group. The number of bifidobacteria in feces also significantly increased compared with the placebo group. In an in vitro study, LF and tryptic hydrolysate of LF, but not peptic hydrolysate of LF, upregulated the growth of Bifidobacterium longum ATCC15707 when added to the culture. These results demonstrate the capability of the enteric-coated tablets containing LF and LB in improving intestinal function and suggest that they have a growth promoting function for bifidobacteria.

【 授权许可】

Unknown