A Canine Case of Discoid Lupus Erythematosus with Circulating Autoantibody

Journal of Veterinary Medical Science

Motoko SHIMIZU¹  Hideo OBATA¹  Toshiroh IWASAKI¹  Hitoshi KITAGAWA¹  Yoshihide SASAKI¹  Tokuma YANAI¹ 

关键词: canine;    circulating autoantibody;    discoid lupus erythematosus;   

DOI  :  10.1292/jvms.57.1097

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(1)A nine-year-old Shetland sheepdog was diagnosed as discoid lupus erythematosus by clinical features, histopathologic findings, positive direct immunofluorescence, negative antinuclear antigen test and the absence of multisystemic diseases. The indirect immunofluorescence test of this patient dog with the salt split skin showed the deposition at the bottom of the cleft at basement membrane zone (BMZ). Western immunoblotting revealed the 120 kDa and the 85 kDa proteins targeted by the autoantibody. These proteins did not correspond with the known BMZ component.

【 授权许可】

Unknown