Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs inmouse perinatal development

Journal of Veterinary Medical Science

Naoko OHTANI¹  Hiroki INOUE¹  Kentaro TANEMURA²  Risa YABUSAKI¹  Hiroshi YOKOTA¹  Sumito TSUSHIMA¹  Hidetomo IWANO¹  Nanako KOIKE¹ 

[1]Laboratory of Veterinary Biochemistry, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069�?8501, Japan

[2]Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 1�?1 Amamiya-machi, Tsutsumidori, Aoba-ku, Sendai, Miyagi 981�?8555, Japan

关键词: Bisphenol A;    Bisphenol AF;    Bisphenol F;    UDP glucuronosyl transferase (UGT);   

DOI  :  10.1292/jvms.15-0197

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(37)Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function.BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affectreproductive organ development, brain development, metabolic disease and post-natalbehavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane)and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacementsfor BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but thiseffective metabolizing system is weak in the fetus. In the present study, we demonstratedthat hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, inthe fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in thefetus and newborn pups, and was increased to the same level as BPA post-partum. Inconclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolismduring the perinatal period, suggesting that the metabolism of individual Bisphenolanalogs requires assessment to properly gauge their risks.

【 授权许可】

Unknown