Permeability of Mammary Gland Capillaries to Ferritin in Mice

Journal of Veterinary Medical Science

Hayao NISHINAKAGAWA¹  Junichi OTSUKA¹  Masamichi KUROHMARU¹  Mitsuharu MATSUMOTO¹  Yoshihiro HAYASHI¹ 

关键词: capillary;    ferritin;    mammary gland;    mouse;    permeability;   

DOI  :  10.1292/jvms.56.65

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)Cited-By(4)The permeability of mammary gland capillaries to ferritin was investigated by transmission electron microscopy. In virgin mice, the concentration of tracers in perivascular spaces increased with the advance of time after injection. The ferritin never passed through the intercellular junction of the endothelial cells. In the early to middle stages of lactation, numerous ferritin particles were observed in the basal cytoplasm of alveolar epithelial cells after only 1 min of circulation. These findings indicate that a large amount of materials quickly pass through the capillary walls during these periods for milk production. The number of vesicles labelled with ferritin per μm2 of endothelial cytoplasm decreased remarkably in the late stage of lactation. This result suggests that the permeability of vesicles declines along with the degeneration of alveolar cells.

【 授权许可】

Unknown