Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents

Public Health Nutrition

Kuo-Ching Chao¹  Chyi-Huey Bai¹  Wen-Harn Pan¹  Tzu-chieh Huang¹  Eddy Owaga¹  Chun-Chao Chang¹  Jung-Su Chang¹ 

关键词: Alanine aminotransferase;    Dyslipidaemia;    Hb;    Taiwanese adolescents;    Liver function;   

DOI  :  10.1017/S1368980015002293

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

AbstractObjectiveFe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents.DesignA population-based, cross-sectional study. SettingNational Nutrition and Health Survey in Taiwan (2010–2011, adolescents).SubjectsHealthy adolescents aged 13–18 years.ResultsIn total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd 0·1) years (boys, 15·3 (sd 0·1) years; girls, 15·2 (sd 0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), 12 U/l) than the reference (Q1 of Hb, 15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb,

【 授权许可】

Unknown