Comparison of Antibody Titers in Rabbits Following Immunization with Inactivated Influenza Virus via Subarachnoidal or Subcutaneous Route

Journal of Veterinary Medical Science

Kenji OCHIAI²  Yoshihiro SAKODA³  Takashi UMEMURA²  Jae-Ho SHIN²  Jae Hoon KIM¹ 

[1] Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Cheju National University;Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University;Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University

关键词: cerebrospinal fluid;    influenza virus;    intrathecal immunization;   

DOI  :  10.1292/jvms.69.1167

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(25)Cited-By(4)Rabbits were immunized with inactivated influenza virus via the subarachnoidal (SA) or subcutaneous (SC) route, and the antibody titers in cerebrospinal fluid (CSF) and serum were assayed. There were no nervous signs or morphological lesions related to SA immunization. In the SC group, the antibody titer was elevated in serum, but not elevated in CSF. In the SA group, the antibody titer was significantly elevated in serum and even in CSF, and their antibody titers were much greater than in the SC group. The present results suggest that intrathecal immunization is more effective than SC immunization at inducing a protective immune response against the transneural spread of viruses.

【 授权许可】

Unknown