Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method

Journal of Pharmacological Sciences

Tetsuji Yae²  Kazuhiko Shibata²  Hidenori Sagara²  Hiroaki Araki³  Toshiaki Sendo¹  Yoshihisa Kitamura⁴  Katsuya Suemaru³  Yutaka Gomita⁵ 

[1] Department of Hospital Pharmacy, Okayama University Medical School, Japan;Department of Pharmaceutical Information Sciences, Matsuyama University, Japan;Division of Pharmacy, Ehime University Hospital, Japan;Department of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan;Shujitsu University, Japan

关键词: nicotine;    methyllycaconitine;    dihydro-β-erythroidine;    intracranial self-stimulation;    motivation;   

DOI  :  10.1254/jphs.08168FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(50)Cited-By(8)Recently, it was demonstrated that the priming stimulation effect (PSE) of intracranial self-stimulation (ICSS) with the runway method can be used as a model system to study the motivation that contributes to specific behaviors. It was postulated that these behaviors could be used to compare the effects of various drugs on the mechanism of motivation. In the present study, the influences of nicotine, methyllycaconitine (α7 nicotine-receptor antagonist), and dihydro-β-erythroidine (α4β2 nicotine-receptor antagonist) on motivation were examined using the runway method for ICSS. Electrodes were implanted into the medial forebrain bundle of Wistar rats. The rats ran to the goal lever to get the reward (50 – 200 μA, 0.2 ms, 60 Hz) and pretrial electric stimulation (priming stimulation) in the medial forebrain bundle was performed. The experiment measured the running time from the start box until the rat pressed the goal lever for the reward stimulation. Under these reward and priming stimulation conditions, nicotine (0.2 mg/kg) induced a significant increase in running speed. The nicotine receptor antagonist α4β2 rather than α7 showed a dose-dependent antagonistic action on the effect of nicotine on running speed. These results demonstrate that nicotine enhances the running speed towards the goal lever via α4β2 nicotinic receptors and suggest that α4β2 nicotinic receptors influence the brain mechanism of motivation.

【 授权许可】

Unknown