Complex Apocrine Carcinoma with Dominant Myoepithelial Proliferation in a Dog

Journal of Veterinary Medical Science

Takumi OHISHI¹  Yuri HOJO¹  Liyun WANG¹  Ayako SHIRAKI¹  Kunitoshi MITSUMORI¹  Kazuhiko SUZUKI¹  Makoto SHIBUTANI¹  Takuma TSUCHIYA¹ 

[1] Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan

关键词: canine;    diagnosis;    pathology;    skin;    tumor;   

DOI  :  10.1292/jvms.11-0532

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(13)Cited-By(1)A rare case of complex apocrine carcinoma displaying dominant myoepithelial proliferation developed in the right leg subcutis of a 10-year-old male dog. The major cell population consisted of diffusely proliferating p63-expressing neoplastic cells that were largely myoepithelial in origin co-expressing α-smooth muscle actin. A small portion of the cell population consisted of concomitant basal epithelial cells lacking α-smooth muscle actin expression. The minor population consisted of p63-negative apocrine gland cells that expressed cytokeratin 8. The myoepithelial cell population showed a rather stronger proliferation activity than did the apocrine epithelial population. Thus, this tumor might have been derived from basal epithelial cells characterized by more predominant myoepithelial differentiation than luminal apocrine epithelial differentiation.

【 授权许可】

Unknown