Let-7 related genetic variation and risk of metabolic syndrome in a Chinese population

Endocrine Journal

Yu-Xiang Yan²  Li-Juan Wu²  Jie Zhang²  Jing Dong¹  Wei Wang²  Shuo Wang²  Yan He² 

[1]Health Medical Examination Center, Xuanwu Hospital, Capital Medical University, Beijing, China

[2]Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China

关键词: MicroRNA;    Let-7;    Polymorphism;    Metabolic syndrome;    Risk factor;   

DOI  :  10.1507/endocrj.EJ15-0236

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(1)MicroRNA (miRNA) related genetic variation may change miRNA binding affinity and mRNA expression levels of the target genes, thus leading to altered metabolic parameters.This study explored the influence of let-7 related single nucleotide polymorphisms (SNPs) on individual susceptibility to metabolic syndrome (MetS) in a Chinese population.Seven SNPs located at the pri-let-7 gene region, pre-let-7 gene region or 3’-UTR of the KRAS gene were selected.The SNPs were genotyped in 503 MetS patients and 529 normal controls using the high-throughput Sequenom genotyping platform.Unconditional logistic regression analysis was utilized to estimate the association between these SNPs and the risk of MetS.There are three SNPs significantly associated with MetS.The A allele of rs17276588 was associated with an increased risk effect for MetS (Adjusted OR=1.75, 95%CI 1.37-2.25, P<0.001).Rs10993081 AG genotype was significantly associated with an increased risk of MetS compared with AA genotypes (Adjusted OR=1.42, 95%CI 1.11-1.83, P=0.006).Rs10877887 TC genotype was significantly associated with an increased risk of MetS compared with TT genotypes (Adjusted OR=1.52, 95% CI 1.16-1.99, P=0.002).Additionally, interactions between rs7045890 and rs712, rs17276588 and rs10877887 were significantly associated with risk of MetS.In conclusion, our study found that let-7 related genetic variation is associated with MetS and may contribute to the susceptibility of MetS.Larger, prospective studies are warranted to validate our findings.

【 授权许可】

Unknown