Thyroxine treatment may be useful for subclinical hypothyroidism in patients with female infertility

Endocrine Journal

Eijun Nishihara¹  Hirotoshi Nakamura¹  Waka Yoshioka¹  Mitsuru Ito¹  Akane Ide¹  Nobuyuki Amino¹  Shino Kang¹  Akira Miyauchi¹  Takumi Kudo¹ 

[1] Kuma Hospital, Center for Excellence in Thyroid Care, Kobe 650-0011, Japan

关键词: Subclinical hypothyroidism;    Infertility;    Thyroxine therapy;    Anti-thyroid antibodies;    Pregnancy;   

DOI  :  10.1507/endocrj.EJ14-0300

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(24)Cited-By(2)Infertile women sometimes associated with subclinical hypothyroidism (SCH).The guidelines of the American Endocrine Society, and American Association of Clinical Endocrinologists and American Thyroid Association recommend treatment with thyroxine (T4) for patients with SCH who want to have children.We examined 69 female infertile patients with SCH and the effects of levothyroxine (l-T4) therapy on pregnancy rates and pregnancy outcomes were observed.Fifty-eight (84.1%) patients successfully conceived during the T4 treatment period (Group A), although 17 patients (29.3%) had miscarriage afterward.The remaining 11 patients continued to be infertile (Group B).The median TSH value in Group A before the T4 treatment was 5.46 μIU/mL (range 3.1-13.3) and this significantly decreased to 1.25 μIU/mL (range 0.02-3.75) during the treatment (p p < 0.001).Shortening of the infertile period after the T4 therapy was observed not only in patients who were treated with assisted reproductive technology (ART) but also in patients who conceived spontaneously in Group A.Administered T4 dose was 54.3±14.2 μg before pregnancy and 68.5±22.8 μg during pregnancy (p < 0.001).Anti-thyroid autoantibodies were identified in 42.0% of all patients and no significant difference was observed in positivity between Group A and Group B.High successful pregnancy rate and shorter duration of infertility until pregnancy after T4 treatment strongly suggest that T4 enhanced fertility in infertile patients with SCH.

【 授权许可】

Unknown