Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil

Brazilian Journal of Infectious Diseases

Carvalho, DM¹  Barroso, David Eduardo²  Solari, CA⁴  Nogueira, SA²  Rebelo, MC²  Zahner, V⁴  Soares, V²  Casagrande, ST³ 

[1] Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;Instituto Estadual de Infectologia São Sebastião, Rio de Janeiro, Brazil;Instituto Adolfo Lutz, São Paulo, Brazil;Instituto Oswaldo Cruz, Rio de Janeiro, Brazil

关键词: Neisseria meningitidis;    meningococcal disease;    epidemic;    meningitis;    sepsis.;   

DOI  :  10.1590/S1413-86702010000300008

来源: Contexto

【 摘 要 】

The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C^®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a significant shift in the age distribution toward older age groups and an increase of sepsis. Serogroup C epidemics are a recurrent problem in Rio de Janeiro, which can be hindered with the introduction of a conjugate vaccine. We hope the data presented here brings useful information to discuss vaccines strategies and early management of suspected cases.

【 授权许可】

CC BY-NC-ND