Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs

Ciência Rural

Barros Sobrinho, Alexandre Augusto Franchi¹  Kobashigawa, Karina Kamachi¹  Santo, Paloma do Espírito¹  Cunha Junior, Armando Silva²  Laus, José Luiz¹  Lima, Tiago Barbalho¹  Chacaltana, Flor Diana Yocoay Claros¹  Aldrovani, Marcela¹  Padua, Ivan Martinez¹  Vieira, Lorena Carla² 

[1] Universidade Estadual Paulista (UNESP), Jaboticabal, Brazil;Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil

关键词: dog;    cataract surgery;    inflammation;    PLGA;    dexamethasone;   

DOI  :  10.1590/0103-8478cr20160179

学科分类：农业科学（综合）

来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais

【 摘 要 】

:This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography showed gradual device shrinkage, with only remnants remaining at postoperative day (POD) 60. Signs of uveitis were observed in 35% of the DG on POD 7, but by POD 14, 50% of eyes showed signs of uveitis and these eyes required local steroid therapy. The intraocular pressure (IOP) was higher in the DG than in the CG immediately after surgery. IOP did not differ on POD 7 and POD 14, but was lower during the late postoperative period (POD 30 to 90). Flare values were greater in the DG than in the CG immediately following surgery, but showed no subsequent differences. In summary, the intravitreal dexamethasone device did not adequately control intraocular inflammation in dogs undergoing phacoemulsification.

【 授权许可】

Unknown